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121 National Center for Biotechnology Information (2023e)

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Additionally, the key pathological features of RA, such as fibroblast-like synoviocyte (FLS) proliferation, hyperplastic synovial lining, articular cartilage injury, bone destruction, reduced joint space, swollen inflamed synovial membrane, and angiogenesis, are highlighted

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This is a normal physiological response, not a sign of weakness

That means reaching at least 10mg (ideally 15mg) and staying at that dose for a minimum of 12 weeks before concluding it has failed